Background:

The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair(NER). It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

COFS3, ERCC5, ERCM2, UVDR, XPG, XPGC

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

excision repair cross-complementing rodent repair deficiency, complementation group 5

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

133 kDa, Observed 200 kDa

Form:

liquid

Applications:

ELISA, WB, IP

Recommended dilution:

WB: 1:200-1:2000; IF: 1:20-1:200; IP: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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