Background:

U2 auxiliary factor(U2AF), comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. U2(RNU2) small nuclear RNA auxiliary factor 1(U2AF1,synonyms: RN, FP793, U2AF35, U2AFBP, RNU2AF1)is the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. The U2AF1 gene is localized to chromosome 21q22.3, which is the critical region for three diseases, progressive myoclonus epilepsy, autoimmune polyglandular disease type 1, and one form of bipolar affective disorder.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

DKFZp313J1712, FP793, RN, RNU2AF1, U2AF1, U2AF35, U2AFBP

Specificity:

Human

Host:

Mouse

Isotype:

IgG1

Immunogen:

U2 small nuclear RNA auxiliary factor 1

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

28 kDa, 0beserved 40 kDa

Form:

liquid

Applications:

ELISA, WB, IHC, IP

Recommended dilution:

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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