Background:

TTRAP is a 5-prime tyrosyl-DNA phosphodiesterase that is required for efficient repair of topoisomerase II-induced DNA double-strand breaks. Thus it can remove lots of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, generating a free 5' phosphate to DNA. It also has 3'-tyrosyl DNA phophodiesterase activity, but not so efficient as TDP1. TTRAP functions as a negative regulator of ETS1 and inhibit nuclear factor-kappa-B activation.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

5 Tyr DNA phosphodiesterase, AD022, dJ30M3.3, EAP2, EAPII, ETS1 associated protein 2, ETS1 associated protein II, TDP2, TTRAP, Tyr DNA phosphodiesterase 2

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

TRAF and TNF receptor associated protein

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

45 kDa

Form:

liquid

Applications:

ELISA, WB, IP

Recommended dilution:

WB: 1:500-1:5000; IP: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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