Background:

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

TIPIN, FLJ20516, TIMELESS interacting protein

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

TIMELESS interacting protein

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

48kd

Form:

liquid

Applications:

ELISA, WB

Recommended dilution:

WB: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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