Background:

Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

NRSF, REST, X2 box repressor, XBR

Specificity:

Human, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

RE1-silencing transcription factor

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

122 kDa, 200kd

Form:

liquid

Applications:

ELISA, WB, IP

Recommended dilution:

WB: 1:500-1:1000; IP: 1:500-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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