Background:

REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function：Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1(mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes(By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication(By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

HIF-1 responsive protein RTP801,Protein regulated in development and DNA damage response 1,REDD-1,REDD1, RTP801,DDIT4

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

DNA-damage-inducible transcript 4

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

35 kDa

Form:

liquid

Applications:

ELISA, IHC, IP, WB

Recommended dilution:

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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