Background:

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

FLJ26459, P130, pRb2, Rb2, RBL2, RBR 2, retinoblastoma like 2(p130), Retinoblastoma like protein 2

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

retinoblastoma-like 2(p130)

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

130 kDa

Form:

liquid

Applications:

ELISA

Recommended dilution:

WB: 1:200-1:2000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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