Background:

Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

FAM38A, KIAA0233

Specificity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

family with sequence similarity 38, member A

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

250kd

Form:

liquid

Applications:

ELISA, WB,IHC

Recommended dilution:

WB: 1:200-1:1000; IHC: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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