Background:

NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2

Specificity:

Human, Mouse, Rat, Zebrafish

Host:

Rabbit

Isotype:

IgG

Immunogen:

nuclear factor(erythroid-derived 2)-like 2

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

70-100 kDa

Form:

liquid

Applications:

ELISA, IP, WB, IHC, FC

Recommended dilution:

WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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