Background:

Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance(By similarity). Plays a role in the human tumorigenesis(PubMed:22748190).

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

CIR2, NENF, NEUDESIN, SCIRP10, SPUF, SPUF protein

Specificity:

Human, Mouse

Host:

Mouse

Isotype:

IgG2a

Immunogen:

neuron derived neurotrophic factor

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

18 kDa

Form:

liquid

Applications:

ELISA, IHC, WB,IF

Recommended dilution:

WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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