Background:

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences(E-boxes)(5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase(TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase(TYR) and tyrosinase-related protein 1(TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

bHLHe32, MI, MITF, WS2A

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

microphthalmia-associated transcription factor

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

60-65kd

Form:

liquid

Applications:

ELISA, WB, FC, IP

Recommended dilution:

WB: 1:1000-1:10000; IP: 1:500-1:5000

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com