Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms(aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

HsT17454, MAP kinase kinase 5, MAP2K5, MAPK/ERK kinase 5, MAPKK 5, MAPKK5, MEK 5, MEK5, MKK5, PRKMK5

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

mitogen-activated protein kinase kinase 5

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

50kd

Form:

liquid

Applications:

ELISA, WB, IHC, IF

Recommended dilution:

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:100

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com