Background:

MYL6B (Myosin light chain 6B) is a heavy chain regulator found in smooth muscle and non-muscle Myosin complexes. Three general classes of Myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Contractile activity in smooth muscle is regulated by the calcium/calmodulin-dependent phosphorylation of myosin light chain by myosin light chain kinase. Myosin heavy chains are encoded by the MYH gene family and have Actin-activated ATPase activity which generates the motor function of Myosin. Although it contains three of the EF-hand domains common to Actin and other Myosin regulating proteins, MYL6B does not bind calcium during contraction. It is primarily found in a hexamer consisting of four light chains and two heavy chains.

Specificity:

MYL6B polyclonal antibody detects endogenous levels of MYL6B protein.

Alternative names:

MLC1SA; Myosin light chain 6B;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human MYL6B.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 23 kDa

Applications:

WB

Usage:

WB 1:200 - 1:500

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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