Background:

LRSAM1 (leucine-rich repeat and sterile α motif-containing protein 1), also known as Tsg101-associated ligase, is a 723 amino acid E3 ubiquitin-protein ligase that mediates the monoubiquination of tsg 101, a regulator of vesicular trafficking. This leads to inactivation of the sorting of endocytic and exocytic cargos, such as EGF receptors and HIV-1 viral proteins. Mutations within the LRSAM1 gene have been identified in patients with Charcot-Marie-Tooth disease. There are three isoforms of LRSAM1 that are produced as a result of alternative splicing events.

Specificity:

LRSAM1 polyclonal antibody detects endogenous levels of LRSAM1 protein.

Alternative names:

TAL; UNQ6496/PRO21356; E3 ubiquitin-protein ligase LRSAM1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human LRSAM1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 84 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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