Background:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, β catenin, β-catenin

Specificity:

Human, Mouse, Rat, Pig

Host:

Mouse

Isotype:

IgG1

Immunogen:

catenin(cadherin-associated protein), beta 1, 88kDa

Purification:

protein A+G purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

90 kDa

Form:

liquid

Applications:

ELISA, IF, WB, IHC, IP

Recommended dilution:

WB: 1:2000-1:20000; IP: 1:1000-1:5000; IHC: 1:200-1:1000; IF: 1:20-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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