Background:

STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

D11S4896E, GOK, STIM1, stromal interaction molecule 1

Specificity:

Human, Mouse, Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

stromal interaction molecule 1

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

80kd

Form:

liquid

Applications:

ELISA, WB, IP, IHC, IF, FC

Recommended dilution:

WB: 1:500-1:1000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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