Background:

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene(PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6(IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1(PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation(By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation(PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. This antibody is a mouse monoclonal antibody raised against residues near the N terminus of human STAT3.

Clonality:

monoclonal

Classification:

Primary antibody

Alternative names:

Acute phase response factor, APRF, FLJ20882, HIES, STAT3

Specificity:

Human, Mouse, Rat

Host:

Mouse

Isotype:

IgG2a

Immunogen:

signal transducer and activator of transcription 3(acute-phase response factor)

Purification:

Protein A+G purification

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

88 kDa

Form:

liquid

Applications:

ELISA, WB, IHC, IF, IP

Recommended dilution:

WB: 1:2000-1:20000; IP: 1:1000-1:10000; IHC: 1:50-1:500; IF: 1:50-1:500

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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