Background:

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.The antibody recognize both un-phospho and phospho-Ser(330) of FANCD2.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

DKFZp762A223, FA D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, FLJ23826, Protein FACD2

Specificity:

Human, Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

Fanconi anemia, complementation group D2

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

150-155kd

Form:

liquid

Applications:

ELISA, WB, IHC, IP

Recommended dilution:

WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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Email: info@sobekbio.com

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