Background:

Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from COL18A1(also named as KNO). It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It potently inhibits endothelial cell proliferation and inhibits endothelial cell angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor(bFGF/FGF-2) and vascular endothelial growth factor(VEGF).

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

Endostatin

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

collagen, type XVIII, alpha 1

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

19 kDa, 27 kDa

Form:

liquid

Applications:

ELISA, WB, IHC

Recommended dilution:

WB: 1:200-1:1000; IHC: 1:20-1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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