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Background:
Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine(m1A)(PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine(m1A) and 3-methylcytosine(m3C) by oxidative demethylation(PubMed:12486230, PubMed:12594517, PubMed:16174769). Has a strong preference for single-stranded DNA(PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3(PubMed:22055184). Also acts on RNA(PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine(m1A) RNA, an epigenetic internal modification of messenger RNAs(mRNAs) highly enriched within 5'-untranslated regions(UTRs) and in the vicinity of start codons(PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:22055184, PubMed:16858410).
Clonality:
polyclonal
Classification:
Primary antibody
Alternative names:
ABH3, ALKBH3, DEPC 1, DEPC1, FLJ43614, PCA1, Prostate cancer antigen 1
Specificity:
Human, Mouse
Host:
Rabbit
Isotype:
IgG
Immunogen:
alkB, alkylation repair homolog 3(E. coli)
Purification:
Immunogen affinity purified
Purity:
≥95% as determined by SDS-PAGE
Calculated molecular weight:
33 kDa, observed 25 kDa
Form:
liquid
Applications:
ELISA, WB, IHC
Recommended dilution:
WB: 1:500-1:5000; IHC: 1:20-1:200
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com