Background:

Binds to DNA, at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons(UL1) specific genetic program and for the inactivation of deep-layer neurons(DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

Clonality:

polyclonal

Classification:

Primary antibody

Alternative names:

DNA binding protein SATB2, KIAA1034, SATB homeobox 2, SATB2

Specificity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

SATB homeobox 2

Purification:

Immunogen affinity purified

Purity:

≥95% as determined by SDS-PAGE

Calculated molecular weight:

69-83 kDa

Form:

liquid

Applications:

ELISA, WB, IHC

Recommended dilution:

WB: 1：200-1：2000; IHC: 1：20-1：200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

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