Background:

Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.

Alternative names:

Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK

Clonality:

Monoclonal

Species reactivity:

Human, Rat, Mouse

Source:

Mouse

Species:

Human

Cellular localization:

Intermediate filament

Isotype:

IgG1

Immunogen:

Synthetic Peptide

Concentration:

1mg/ml

Observed band:

51kDa

Applications:

IHC

Recommended dilution:

IHC 1:200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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Email: info@sobekbio.com

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