Background:

Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.

Alternative names:

Mixed lineage kinase domain like protein, FLJ34389

Clonality:

Monoclonal

Species reactivity:

Human

Source:

Mouse

Species:

Human

Cellular localization:

Cell membrane, Cytoplasm, Membrane

Isotype:

IgG1

Immunogen:

Synthetic Peptide

Concentration:

1mg/ml

Observed band:

54kDa

Applications:

IHC

Recommended dilution:

 IHC 1:100-200

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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