Background:

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal . CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs . In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly. Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target.

Alternative names:

XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the Internal region of human CRM1 around the acetylation site of K568.

Concentration:

1mg/ml

Applications:

WB, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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