Background:

Chk2(Checkpoint kinase 2) is also named as CDS1, CHEK2, RAD53 and belongs to the CHK2 subfamily. It is a protein kinase that is activated in response to DNA damage and involved in cell cycle arrest. It also mediates the induction of senescence in fibroblasts, but is dispensable for the induction of telomere dysfunction checkpoints at the stem and progenitor cell level. This protein can exsit as a dimer. Active forms of CHEK2 devoid of phosphorylation at Thr-68 can form unstable dimers. Defects in CHEK2 is a cause of susceptibility to breast cancer (BC). It has 12 isoforms produced by alternative splicing.

Alternative names:

CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2

Clonality:

Polyclonal

Reactivity:

Human,Monkey

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from human Chk2 around the phosphorylation site of S516.

Concentration:

1mg/ml

Applications:

WB, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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