Background:

Adaptor-related protein complex 2 (AP-2 complexes) operates during receptor-mediated endocytosis to initiate clathrin assembly, associates with membrane-bound receptors and mobilizes encodytic accessory factors. AAK1 (AP2 associated kinase 1), also known as adaptor-associated kinase 1, is a 961 amino acid protein belonging to the protein kinase superfamily and the serine/threonine protein kinase family. Encoded by a gene that maps to human chromosome 2p14, AAK1 participates in ATP and nucleotide binding, protein serine/threonine kinase functions and transferase activity. AAK1 phosphorylates a subunit of the AP-2 complex, which leads to binding of AP-2 to sorting signals in membrane-bound receptors, resulting in receptor endocytosis. AAK1 contains one protein kinase domain, with kinase activity stimulated by clathrin, and exists as two alternatively spliced isoforms.

Alternative names:

AAK1; KIAA1048; AP2-associated protein kinase 1; Adaptor-associated kinase 1

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat,Monkey

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the Internal region of human AAK1. at AA rangle； 240-320

Concentration:

1mg/ml

Applications:

WB, IHC, IF, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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