Background:

APIP (Apaf-1-interacting protein), also known as APIP2, is a member of the aldolase class II family and has a highly conserved C-terminal from C. elegans to humans. It is ubiquitously expressed, with high expression levels in heart, kidney and skeletal muscle. Alternative splicing produces two isoforms of APIP. Isoform 1 is the full length, 242 amino acid protein; isoform 2 is missing residues 1-38 and contains a distinct sequence for amino acids 39-53. APIP plays an important role in preventing muscle ischemic damage. It suppresses hypoxia-induced cell death by inducing the activation of Akt and ERK 1/2, which are responsible for inhibition of caspase-9 via phosphorylation, and competing with caspase-9 to bind the caspase recruitment domain (CARD) of Apaf-1. Through these mechanisms, APIP negatively regulates the activation of caspase-9 and Apaf-1-mediated cell death.

Alternative names:

APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19; dJ179L10.2; likely ortholog of mouse monocyte macrophage 19

Clonality:

Polyclonal

Reactivity:

Human

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the C-terminal region of human Apaf-1-ALT. at AA rangle； 260-340

Concentration:

1mg/ml

Applications:

WB, IHC, IF, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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