Background:

The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2S1, a member of the CYP2 subfamily, is expressed in a wide variety of epithelial cells in extrahepatic tissues, specifically the respiratory tract, gastrointestinal tract, skin and other tissues frequently exposed to xenobiotics. CYP2S1 localizes to the endoplasmic reticulum where it metabolizes both endogenous and exogenous substrates such as retinoic acid, aromatic hydrocarbons and some cellular substances. CYP2S1 is also involved in the metabolism of topical drugs and mediates the response to photochemotherapy in psoriasis. Dioxin induces CYP2S1, while aryl hydrocarbon receptor (AHR) and aryl hydrocarbon nuclear translocator (ARNT) regulate this induction.

Alternative names:

CYP2S1; Cytochrome P450 2S1; CYPIIS1

Clonality:

Polyclonal

Reactivity:

Human,Mouse

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the Internal region of human CYP2S1. at AA rangle； 140-220

Concentration:

1mg/ml

Applications:

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Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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