Sgo2 Rabbit pAb ES4904
Specifications
| 50µl / 100µl |
Background:
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
Alternative names:
SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin
Clonality:
Polyclonal
Reactivity:
Human
Source:
Rabbit
Isotype:
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Immunogen:
Synthesized peptide derived from the Internal region of human Sgo2. at AA rangle; 650-730
Concentration:
1mg/ml
Applications:
IHC, ELISA
Recommende dilutions:
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Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
More info:
Email: info@sobekbio.com
Orders:
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