Background:

LEP encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations inLEP and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in LEP has also been linked to type 2 diabetes mellitus development. LEP (Leptin) is a Protein Coding gene. Diseases associated with LEP include Obesity, Morbid, Due To Leptin Deficiency and Obesity Due To Congenital Leptin Deficiency. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Transcription factor regulation in adipogenesis.

Alternative names:

LEP; OB; OBS; Leptin; Obese protein; Obesity factor

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the N-terminal region of human Ob.

Concentration:

1mg/ml

Applications:

IHC, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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