Background:

The protein encoded by ATM (ATM serine/threonine kinase) belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names:

ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Clonality:

Polyclonal

Reactivity:

Human

Source:

Rabbit

Isotype:

Request info at info@sobekbio.com

Immunogen:

Synthesized peptide derived from human Atm around the non-phosphorylation site of S1981.

Concentration:

1mg/ml

Applications:

IHC, ELISA

Recommende dilutions:

Request info at info@sobekbio.com

Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com