β-Catenin Rabbit pAb ES8174
Specifications
| 50µl / 100µl |
Background:
The protein encoded by CTNNB1 (catenin beta 1) is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.
Alternative names:
CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Clonality:
Polyclonal
Reactivity:
Mouse,Rat
Source:
Rabbit
Isotype:
Request info at info@sobekbio.com
Immunogen:
Recombinant Protein
Concentration:
1mg/ml
Applications:
WB
Recommende dilutions:
Request info at info@sobekbio.com
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com
