Background:

Semaphorins comprise a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular "semaphorin" domain of approximately 500 amino acids containing 14-16 cysteines, many blocks of conserved sequences and no obvious repeats (2-4). The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. These semaphorin proteins regulate the growth of the axons during embryogenesis by repelling growth cones from regions of high semaphorin expression (2,4). Also designated CD108, Semaphorin 7A (SEMA7A) promotes axonal growth in the central nervous system and plays a critical role in negative regulation of T cell activation and function.

Alternative names:

Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108)

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat

Source:

Rabbit

Isotype:

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Immunogen:

Synthetic peptide from human protein at AA range； 101-150

Concentration:

1mg/ml

Applications:

IHC, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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