Background:

Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed: 11053434, PubMed: 15930133, PubMed: 22514632, PubMed: 28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed: 24105263, PubMed: 28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed: 28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed: 12070139, PubMed: 19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed: 28377464). Does not activate transcriptional cholesterol sensing (PubMed: 28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed: 21322544).

Alternative names:

N/A

Clonality:

Polyclonal

Reactivity:

Human,Mouse

Source:

Rabbit

Isotype:

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Immunogen:

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Concentration:

1mg/ml

Applications:

WB, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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