Background:

Normal Abl function is essential for humans because Philadelphia chromosome translocation involving the ABL gene causes chronic myelogenous leu-kemia. Abl associates with a broad range of targets and appears to function in various signaling pathway. Cables1, a 568 amino acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5). Cables1 bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables1 also has six potential SH3 binding motifs (PXXP) clustered around the amino-terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables1 forms a trimolecular complex with Cdk5 and Abl in vivo. All three proteins co-localize within cortical axons, particularly in their growth cones. Cables1 and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.

Alternative names:

CABLES1; CABLES; CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1

Clonality:

Polyclonal

Reactivity:

Human,Mouse

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the C-terminal region of human Cables1. at AA rangle； 530-610

Concentration:

1mg/ml

Applications:

WB, IHC, IF, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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