Background:

A proposed genetic marker of cardiac hypertrophy, CARP (cardiac ankyrin repeat protein) is a nuclear protein with an established role in regulation of cardiac gene expression. A distinct increase in CARP expression occurs in rats with abdominal aorta constriction, spontaneous hypertension and Dahl salt-sensitivity. In cardiomyocytes, CARP inhibits transcription of both cardiac troponin C and atrial natriuretic factor. Specifically, expression of the CARP gene, which lies downstream of the cardiac homeobox gene Nkx2.5, inhibits Nkx2.5 transactivation of atrial natriuretic factor promoter (4,3). An increase in CARP expression is observed in the ventricular tissue of patients with end-stage heart failure. The major Ca2+ binding protein of cardiac sarcoplasmic reticulum (SR), Calsequestrin (CSQ), upregulates the CARP gene, and may contribute to the development of cardiac hypertrophy and fibrosis. TGFβ induces CARP expression in vascular smooth muscle cells (VSMCs), wherein CARP may mediate the inhibitory effects of TGFβ on VSMC proliferation.

Alternative names:

ANKRD1; C193; CARP; HA1A2; Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein

Clonality:

Polyclonal

Reactivity:

Human,Mouse,Rat

Source:

Rabbit

Isotype:

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Immunogen:

Synthesized peptide derived from the C-terminal region of human CARP. at AA rangle； 200-280

Concentration:

1mg/ml

Applications:

WB, IHC, ELISA

Recommende dilutions:

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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