Background:

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Alternative names:

PD-1, Programmed Death-1

Description:

Antibody for flow cytometry

Species reactivity:

Human

Host:

Mouse

Isotype:

Mouse IgG1, κ

Concentration:

0.5 mg/mL

Buffer:

PBS with 0.05% Proclin300

Conjugation:

Unconjugated

Applications:

FCM

Storage:

Store at 2~8°C. Do not freeze.

More info:

Email: info@sobekbio.com

Orders:

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