Background:

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Alternative names:

Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8

Description:

Antibody for flow cytometry

Species reactivity:

Mouse

Host:

Rat

Isotype:

Rat IgG1, κ

Concentration:

0.5 mg/mL

Buffer:

PBS with 0.05% Proclin300, 1% BSA

Conjugation:

FITC

Applications:

ICFCM

Storage:

Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com