Alternative names:

12-HETER, HETER, HETER1

Description:

Human GPR31 full length protein-synthetic nanodisc

Background:

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.[UniProtKB/Swiss-Prot Function]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class A Rhodopsin-like,Chemokines,Chemokine and Receptor,

Expression host:

HEK293

Target:

GPR31

Molecular weight:

The human full length GPR31 protein has a MW of 35.1kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com