Alternative names:

ET-A, ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR

Description:

Human EDNRA full length protein-synthetic nanodisc

Background:

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class A Rhodopsin-like,GPCRDB Other,Peptide GPCRs,Prostaglandin synthesis regulation,Angiogenesis,Cancer,Endothelial Cell Biology,

Expression host:

HEK293

Target:

EDNRA

Molecular weight:

The human full length EDNRA protein has a MW of 48.7kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com