Alternative names:

D4DR

Description:

Human DRD4 full length protein-synthetic nanodisc

Background:

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class A Rhodopsin-like,GPCRDB Other,Monoamine GPCRs,

Expression host:

HEK293

Target:

DRD4

Molecular weight:

The human full length DRD4 protein has a MW of 43.9kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com