Alternative names:

CRF-RB, CRF2, CRFR2, HM-CRF

Description:

Human CRFR2 full length protein-synthetic nanodisc

Background:

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Protein families:

Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class B Secretin-like,Apoptosis,Neurotrophin & Receptors,

Expression host:

HEK293

Target:

CRFR2

Molecular weight:

The human full length CRFR2 protein has a MW of 47.7kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com