Alternative names:

CYSLT1, CYSLT1R, CYSLTR, HMTMF81

Description:

Human CLTR1 full length protein-synthetic nanodisc

Background:

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Protein families:

GPCR,Transmembrane,Druggable Genome,

Protein pathways:

GPCRDB Class A Rhodopsin-like,Cancer,Asthma,Autoimmune & Inflammatory Response,

Expression host:

HEK293

Target:

CLTR1

Molecular weight:

The human full length CLTR1 protein has a MW of 38.5kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com