Alternative names:

MELIOS; SLE1; SLEB1; TIL3

Description:

Human TLR5 full length protein-synthetic nanodisc

Background:

Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

Protein families:

Druggable Genome, Transmembrane

Protein pathways:

Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway

Expression host:

HEK293

Target:

TLR5

Molecular weight:

The human full length TLR5 protein has a MW of 97.8 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com