Alternative names:

AGTRL1; APJ; APJR; HG11

Description:

Human APLNR full length protein-synthetic nanodisc

Background:

A member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

Protein families:

Druggable Genome, GPCR, Transmembrane

Protein pathways:

Neuroactive ligand-receptor interaction

Expression host:

HEK293

Target:

APLNR

Molecular weight:

The human full length APLNR protein has a MW of 42.7 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com