Alternative names:

GLP-1; GLP-1-R; GLP-1R

Description:

Human GLP1R full length protein-synthetic nanodisc

Background:

A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.

Protein families:

Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane

Protein pathways:

Neuroactive ligand-receptor interaction

Expression host:

HEK293

Target:

GLP1R

Molecular weight:

The human full length GLP1R protein has a MW of 53.0 kDa

Formulation / Reconstitution:

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Usage:

Research use only

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com