Alternative names:

ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I

Description:

Recombinant Human ACVRL1 Protein with C-terminal human Fc tag

Background:

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

Molecular characterization:

ACVRL1(Asp22-Gln118) hFc(Glu99-Ala330)

Molecular weight:

The protein has a predicted molecular mass of 36.8 kDa after removal of the signal peptide. The apparent molecular mass of ACVRL1-hFc is approximately 35-70 kDa due to glycosylation.

Tag:

C-Human Fc Tag

Expression host:

HEK293

Target:

ACVRL1

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

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