Alternative names:

Cannabinoid receptor 1;CB-R;Cnr1

Description:

Recombinant mouse CB1 protein with C-terminal human Fc tag

Background:

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Molecular characterization:

Mouse CB1(Met1-Leu118) hFc(Glu99-Ala330)

Molecular weight:

The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of mCB1-hFc is approximately 40-55 kDa due to glycosylation.

Tag:

C-Human Fc Tag

Expression host:

HEK293

Target:

CB1

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

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