Alternative names:

Cell surface glycoprotein MUC18;ell surface glycoprotein P1H12;elanoma cell adhesion molecule;elanoma-associated antigen A32;elanoma-associated antigen MUC18;-endo 1 endothelial-associated antigen;D146

Description:

Recombinant human MUC18 protein with C-terminal 6×His tag

Background:

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.[UniProtKB/Swiss-Prot Function]

Molecular characterization:

MUC18(Val24-Gly559) 6×His tag

Molecular weight:

The protein has a predicted molecular mass of 60.6 kDa after removal of the signal peptide. The apparent molecular mass of MUC18-His is approximately 70-100 kDa due to glycosylation.

Tag:

C-6×His Tag

Expression host:

HEK293

Target:

MUC18

Purity:

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

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