Alternative names:

ROR1;TRKR1

Description:

Recombinant Human ROR1(312-391) Protein with N-terminal human Fc tag

Background:

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Molecular characterization:

hFc(Glu99-Ala330) ROR1(Lys312-Cys391)

Molecular weight:

The protein has a predicted molecular mass of 35.2 kDa after removal of the signal peptide.The apparent molecular mass of hFc- ROR1(312-391) is approximately 35-55 kDa due to glycosylation.

Tag:

N-Human Fc Tag

Expression host:

HEK293

Target:

ROR1

Purity:

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation / Reconstitution:

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Storage:

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

More info:

Email info@sobekbio.com

Orders:

Email orders@sobekbio.com